Below you will find scientific documentation for the following topics:
Gut Dysbiosis and Immune Dysregulation
Epidemic Statistics and Facts
The Impact of the Overuse of Pharmaceuticals
The Impact of Immunization
their Impact on Children€™s Health
1. Michael Camilleri, €œSerotonin in the gastrointestinal tract,€ Current Opinion in Endocrinology, Diabetes and Obesity 16, no. 1 (February 2009): 53-59.
2. IN Pessah et al., €œImmunologic and neurdevelopmental susceptibilities of autism,€ Neurotoxicology 29, no. 3 (May 2008): 532-45;
3. PH Patterson, €œImmune involvement in schizophrenia and autism: Etiology, pathology and animal models,€ Behavioural Brain Research 24 (Dec 2008).
4. Roland Tisch et al., €œDysregulation of T cell peripheral tolerance in type 1 diabetes,€ Advances in Immunology 100 (2008): 125-149.
5. C.A. Edwards and A. M. Parrett, €œIntestinal flora during the first months of life: new perspectives,€ British Journal of Nutrition 88 (2002): S11-S18.
6. A. Borchers et al., €œProbiotics and immunity,€ Journal of Gastroenterology 44 (2009): 26-46.
7. UG Strauch et al., €œInfluence of intestinal bacteria on induction of regulatory T cells: lessons from a transfer model of colitis,€ Gut 54 (2005):1546-1552.
8. Tomas Hrncir et al., €œGut microbiota and lipopolysaccharide content of the diet influence development of regulatory T cells: studies in germ-free mice,€ BMC Immunology 9 (2008): 65
9. Hiroaki Kitano and Kanae Oda, €œRobustness trade-offs and host-microbial symbiosis in the immune system,€ Molecular Systems Biology 2 (2006).
10. Hannah Wexler, €œBacteroides: the Good, the Bad, and the Nitty-Gritty,€ Clinical Microbiology Reviews 20, no. 4 (October 2007): 593-621.
11. Ann M. O€™Hara and Fergus Shanahan, €œThe gut flora as a forgotten organ,€ European Molecular Biology Organization Report 7, no 7 (July 2006): 688-693.
12. Jessica Snyder Sachs, Good Germs, Bad Germs: Health and Survival in a Bacterial World (New York: Hill and Wang, 2007).
13. Patrick Hanaway MD, “Balance of Flora, GALT, and Mucosal Integrity,” Alternative Therapies in Health and Medicine 12, no. 5 (September/October 2006).
14. Leo Galland, MD,€œThe Effect of Intestinal Microbes on Systemic Immunity,€ Excerpted from Power Healing (New York: Random House, 1998) http://mdheal.org/microbes.htm (accessed February 12, 2009).
15. G. Oliveira et al., €œMitochondrial dysfunction in autism spectrum disorders: a population-based study,€ Developmental Medicine and Child Neurology 47 (2005): 185-189.
16. Z. Liu et al., €œTight junctions, leaky intestines, and pediatric diseases,€ Acta Paediatricia 94 (2005): 386-393.
17. J.W. Bennett and M. Klich, €œMycotoxins,€ Clinical Microbiology Reviews (July 2003): 497-516.
18. Yoshinori Mine and Jie Wie Zhang, €œSurfactants Enhance the Tight-Junction Permeability of Food Allergens in Human Intestinal Epithelial Caco-2 Cells,€ International Archives of Allergy and Immunology 130, no. 2 (Feb 2003)
19. Simon Smale and Ingvar Bjarnason, €œDetermining small bowel integrity following drug treatment,€ British Journal of Clinical Pharmacology 56, no. 3 (September 2003): 284-291
20. Ruchika Mohan et al., €œEffects of Bifidobacterium lactis Bb12 Supplementation on Intestinal Microbiota of Preterm Infants: A Double-Blind, Placebo-Controlled, Randomized Study,€ Journal of Clinical Microbiology 44, no. 11 (November 2006): 4025-4031.
21. Samuli Rautava and Erika Isolauri, €œThe Development of Gut Immune Responses and Gut Microbiota: Effects of Probiotics in Prevention and Treatment of Allergic Disease,€ Current Issues in Intestinal Microbiology 3 (2002): 15-22.
22. F. Savino, €œLactobacillus reuteri (American Type Culture Collection Strain 55730) versus simethicone in the treatment of infantile colic: a prospective randomized study,€ Pediatrics 119, no. 1 (January 2007): e124-30.
23. Erica White and Caroline Sherlock, €œThe Effect of Nutritional Therapy for Yeast Infection (Candidiasis) in Cases of Chronic Fatigue Syndrome,€ Journal of Orthomolecular Medicine 20, no. 3 (2005).
24. Natasha Campbell-McBride, Gut and Psychology Syndrome (Cambridge: Medinform Publishing, 2004).
25. Cedars-Sinai Medical Center, “Birth Control Pill: Oral Contraceptive Use May Be Safe, But Information Gaps Remain,” ScienceDaily, January 17, 2009, http://www.sciencedaily.com/releases/2009/01/090114092848.htm (accessed February 26, 2009).
26. Randall Fitzgerald, The Hundred-Year Lie (London: Plume, 2007).
27. Joanne K. Tobacman, €œReview of Harmful Gastrointestinal Effects of Carrageenan in Animal Experiments,€ Environmental Health Perspectives 109, no 10 (October 2001).
28. Gail Hecht, €œMicrobial Pathogens That Affect Tight Junctions,€ in Tight Junctions (New York: CRC Press, 2001): 493-515.
29. Dr. Robyn Cosford, €œOccult Infections, Streptococcus, Biofilms, PANDAS and MINDDD in Autism,€ (lecture, Defeat Autism Now! Conference, San Diego, CA, October 2008).
30. Lindsey A. Moser et al., €œAstrovirus Increases Epithelial Barrier Permeability Independently of Viral Replication,€ Journal of Virology 81, no. 21 (November 2007).
31. RC Bransfield et al., €œThe association between tick-borne infections, Lyme borreliosis and autism spectrum disorders,” Medical Hypotheses 70, no. 5 (November 2007): 967-74.
32. Mark. A. Hyman, M.D, €œIs the Cure for Brain Disorders Outside the Brain?€ Alternative Therapies in Health and Medicine 13, no. 6 (November/December 2007): 6.
33. Mark Jackson, Allergy: The History of a Modern Malady (London: Reaktion Books, 2007).
34. Katrina J. Allen, David J. Hill and Ralf G. Heine, €œFood Allergy in Childhood,€ Medical Journal of Australia 185, no 7 (October 2006).
35. William Walsh, Food Allergies: The Complete Guide to Understanding and Relieving Your Food Allergies (Hoboken, NJ: Wiley John and Sons Inc, 2000): 3.
36. E. Isolauri, S.Rautava, and M. Kalliomaki, €œFood allergy in irritable bowel syndrome: new facts and old fallacies,€ Gut 53, no. 10 (October 2004): 1391-1393.
37. C. Vael et al., €œEarly intestinal Bacteroides fragilis colonization and development of asthma,€ BMC Pulmonary Medicine 8 (September 2008): 19.
38. Nariman Hijazi, Bahaa Abalkhail, and Anthony Seaton, €œDiet and childhood asthma in a society in transition: A study in urban and rural Saudi Arabia,€ Thorax 55, no. 9 (2000): 775-779.
39. CR Morris and MC Agin, €œSyndrome of allergy, apraxia, and malabsorption: characterization of a neurodevelopmental phenotype that responds to omega 3 and vitamin E supplementation,€ Alternative Therapies in Health and Medicine 15, no. 4 (July-August 2009): 34-43.
40. Bryan Jepson, MD, €œConference Presentations: Bryan Jepson, MD,€ Thoughtful House Center for Children, http://www.thoughtfulhouse.org/0405-conf-bjepson.htm, (accessed July 20, 2009).
41. Lynn Waterhouse, €œAutism Overflows: Increasing Prevalence and Proliferating Theories,€ Neuropsychology Review 18 (November 2008): 273-286.
42. Mark Hyman MD, “Autism: Is It All in the Head?” Alternative Therapies in Health and Medicine 14, no. 6 (November/December 2008): 12-15.
43. Hans Rediers et al., €œUnraveling the Secret Lives of Bacteria: Use of In Vivo Expression Technology and Differential Fluorescence Induction Promoter Traps as Tools for Exploring Niche-Specific Gene Expression,€ Microbiology and Molecular Biology Reviews 69, no. 2 (June 2005): 217-261.
44. Dr. Arthur Krigsman, €œGastrointestinal Pathology in Autism: Description and Treatment,€ Thoughtful House Center for Children, paper adapted from a presentation (2000), http://www.thoughtfulhouse.org/0405-conf-akrigsman.htm (accessed March 18, 2009).
45. Dr. Margaret Bauman, €œThe Autism Spectrum Disorders: Beyond Behavior€”Research and Treatment Implications,€ (lecture, UC Davis M.I.N.D. Institute, Distinguished Lecturer Series, Sacramento, CA, January 11, 2006) http://www.ucdmc.ucdavis.edu/mindinstitute/events/dls_recorded_events.html#dls08. (accessed, January 21, 2009).
46. Karoly Horvath et al., €œGastrointestinal abnormalities in children with autistic disorder,€ Journal of Pediatrics 135, no. 5 (November 1999): 559-63.
47. Karoly Horvath and JA Perman, €œAutistic disorder and gastrointestinal disease,€ Current Opinion in Pediatrics 14, no. 5 (October 2002): 583-7.
48. Craig A. Erickson et al., €œGastrointestinal Factors in Autistic Disorder: A Critical Review,€ Journal of Autism and Developmental Disorders 35, no. 6, (December 2005).
49. Dr. Andrew Wakefield, €œThe Seat of the Soul; The Origins of the Autism Epidemic,€ (lecture, Carnegie Mellon University, Pittsburgh, PA, November 17, 2005, Thoughtful House Center for Children, http://www.thoughtfulhouse.org/awakefield_1105.pdf (accessed March 6, 2009).
50. Some of Dr. Wakefield€™s research is available at: http://www.thoughtfulhouse.org/publications.htm (accessed March 7, 2009).
51. B Thjodleifsson et al., €œEffect of Pentavac and measles-mumps-rubella (MMR) vaccination on the intestine,€ Gut 51, no. 6 (December 2002): 816-7.
52. Massimo Montalto et al, €œFecal Calprotectin Concentrations in Patients with Small Intestinal Bacterial Overgrowth,€ Digestive Diseases 26, no. 2 (April 2008): 183-186.
53. L. Shi et al., €œActivation of the maternal immune system alters cerebellar development in the offspring,€ Brain, Behavior, and Immunity 23, no. 1 (January 2009): 116-23.
54. C. Winter et al., €œDopamine and serotonin levels following prenatal viral infection in mouse€”implications for psychiatric disorders such as schizophrenia and autism,€ European Neuropsychopharmacology 18, no. 10 (October 2008): 712-6.
55. GL Nicolson et al., €œEvidence for Mycoplasma ssp., Chlamydia pneumoniae, and human herpes virus-6 coinfections in the blood of patients with autistic spectrum disorders,€ Journal of Neuroscience Research 85, no. 5 (April 2007): 1143-8.
56. K Lancaster et al., €œAbnormal social behaviors in young and adult rats neonatally infected with Borna disease virus,€ Behavioural Brain Research 176, no. 1 (January 2007): 141-8.
57. Sidney Baker, “Canaries and Miners,” Alternative Therapies in Health and Medicine 14, no. 6 (2008): 24-26.
58. Hans Rediers et al., €œUnraveling the Secret Lives of Bacteria: Use of In Vivo Expression Technology and Differential Fluorescence Induction Promotor Traps as Tools for Exploring Niche-Specific Gene Expression,€ Microbiology and Molecular Biology Reviews 69, no. 2 (June 2005): 217-261.
59. Fredrik BÃ¤ckhed et al., €œHost-Bacterial Mutualism in the Human Intestine,€ Science 307 (March 25, 2005): 1915
60. Genome Alberta, €œThe Human Metabolome Project,€ www.metabolomics.ca/ (accessed March 6, 2009).
61. Jessica A. Clark and Craig M. Coopersmith, €œIntestinal crosstalk€”a new paradigm for understanding the gut as the €˜motor€™ of critical illness,€ Shock 28, no. 4 (October 2007): 384-393.
62. Ann M. O€™Hara and Fergus Shanahan, €œThe gut flora as a forgotten organ,€ European Molecular Biology Organization Reports 7, no. 7 (2006).
63. Paul Ashwood et al., €œThe immune response in autism: a new frontier for autism research,€ Journal of Leukocyte Biology 80 (July 2006): 1-15.
64. M. Mary Konstantareas and Soula Homatidis, €œBrief Report: Ear infections in autistic and normal children,€ Journal of Autism and Developmental Disorders 17, no. 4 (December 1987).
65. Germana Moretti, €œWhat every psychiatrist should know about PANDAS: a review,€ Clinical Practice and Epidemiology in Mental Health 4 (May 2008): 13.
66. Harumi Jyonouchi et al., €œImpact of innate immunity in a subset of children with autism spectrum disorders: a case control study,€ Journal of Neuroinflammation 5 (November 2008): 52.
67. Russell C. Dale et al., €œEncephalitis lethargica syndrome: 20 new cases and evidence of basal ganglia autoimmunity,€ Brain 127, no. 1 (October 2003).
68. Anne M. Connolly, MD et al., €œSerum autoantibodies to brain in Landau-Kleffner variant, autism, and other neurologic disorders,€ The Journal of Pediatrics 134, no. 5 (May 1999): 607-13.
69. Diane L. Vargas et al., €œNeuroglial activation and neuroinflammation in the brain of patients with autism,€ Annals of Neurology 57, no. 1 (January 2005): 67-81.
70. Dr. Andrew Wakefield, €œThe Seat of the Soul; The Origins of the Autism Epidemic,€ (lecture, Carnegie Mellon University, Pittsburgh, PA, November 17, 2005) http://www.thoughtfulhouse.org/awakefield_1105.pdf (accessed March 6, 2009).
71. R.E.O. Williams et al., €œThe influence of intestinal bacteria on the absorption and metabolism of foreign compounds,€ Journal of Clinical Pathology 5 Supplement (1971): 125-129.
72. Rowland et al., €œEffects of diet on mercury metabolism and excretion in mice given methylmercury: role of gut flora,€ Archives of Environmental Health 39, no. 6 (1984): 401-8.
73. Center for Science in the Public Interest, €œPetition to Set a Regulatory Limit for Methylmercury in Seafood that Reflects the Risk to Pregnant Women and Children From the Intake of Seafood Containing Methylmercury,€ Letter to Dr. Jane Henney, Commissioner, FDA, July 17, 2000 http://www.cspinet.org/foodsafety/methylmerc_limit.html (accessed March 8, 2009).
74. David Wallinga et al., “Not So Sweet: Missing Mercury and High Fructose Corn Syrup,” Institute for Agriculture and Trade Policy, Minneapolis, Minnesota (January 2009).
75. James B. Adams et al., €œMercury, Lead, and Zinc in Baby Teeth of Children with Autism Versus Controls,€ Journal of Toxicology and Environmental Health 70 (2007).
76. James B. Adams et al., €œMercury in first-cut baby hair of children with autism versus typically-developing children,€ Toxicological & Environmental Chemistry 90, no. 4 (October 2008): 739-753.
77. Amy Holmes et al., €œReduced Levels of Mercury in First Baby Haircuts of Autistic Children,€ International Journal of Toxicology 22 (March 2003): 277-285.
78. Gayle C. Windham et al., €œAutism Spectrum Disorders in Relation to Distribution of Hazardous Air Pollutants in the San Francisco Bay Area,€ Environmental Health Perspectives 114, no. 9 (September 2006): 1438-44.
79. R.F. Palmer et al., €œProximity to point sources of environmental mercury release as a predictor of autism prevalence,€ Health and Place 15, no. 1 (March 2009): 18-24.
80. Richard Lathe, €œEnvironmental factors and limbic vulnerability in childhood autism; Clinical report,€ American Journal of Biochemistry and Biotechnology 4, no. 2 (March 22, 2008).
81. S. Jill James et al., €œMetabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism,€ American Journal of Clinical Nutrition 80, no. 6 (December 2004 ): 1611-1617.
82. Kenneth Blum et al., €œAttention-deficit-hyperactivity disorder and reward deficiency syndrome,€ Neuropsychiatric Disease and Treatment 4, no. 5 (2008) 893-917.
83. Physician€™s Postgraduate Press, €œManaging ADHD in Children, Adolescents, and Adults With Comorbid Anxiety in Primary Care,€ The Primary Care Companion to The Journal of Clinical Psychiatry 9, no. 2 (2007): 129-138.
84. Richard Mackarness, Not All in The Mind (London: Pan, 1976).
85. Dr. William H. Philpott and Dwight K. Kalita PhD, Brain Allergies: The Psychonutrient and Magnetic Connections (Los Angeles: Keats Publishing, 1980) 23.
86. Paul D. Arnold and Margaret A. Richter, €œIs obsessive-compulsive disorder an autoimmune disease?€ Canadian Medical Association Journal 165, no. 10 (November 2001): 1353-1358.
87. Daniel R. Hanson and Irving I. Gottesman, €œTheories of schizophrenia: a genetic-inflammatory-vascular synthesis,€ BMC Medical Genetics 6 (February 2005): 7.
88. Hui-Li Want et al., €œCase-Control Study of Blood Lead Levels and Attention Deficit Hyperactivity Disorder in Chinese Children,€ Environmental Health Perspectives 116, no. 10 (October 2008).
89. Braun et al., €œAssociation of Environmental Toxicants and Conduct Disorder in U.S. Children,€ NHANES 2001-2004 116, no. 7 (July 2008).
90. Carol Joinson et al., €œPsychological Difference Between Children With and Without Soiling Problems,€ Pediatrics 117, no. 5 (May 2006): 1575-1584.
91. M.A. Benninga et al., €œColonic transit times and behaviour profiles in children with defecation disorders,€ Archives of the Diseases of Childhood 89 (2004): 13-16.
92. JM Swanson et al., €œEtiologic subtypes of attention-deficit/hyperactivity disorder: brain imaging, molecular genetic and environmental factors and the dopamine hypothesis,€ Neuropsychology Review 17, no. 1 (March 2007): 39-59.
93. Bistra B Nankova, €œNicotinic Induction of Preproenkephalin and Tyrosine Hydroxylase Gene Expression in Butyrate-Differentiated Rat PC12 Cells: A Model for Adaptation to Gut-Derived Environmental Signals,€ Pediatric Research 53, no. 1 (January 2003): 113-118.
94. Pradeep Mally et al., €œStereospecific Regulation of Tyrosine Hydroxylase and Proenkephalin Genes by Short-Chain Fatty Acids in Rat PC12 Cells,€ Pediatric Research 55, no. 5 (May 2004): 847-854.
The Epidemiological Evidence
1. The Centers for Disease Control and Prevention, €œObesity Prevalence,€ The CDC, http://www.cdc.gov/nccdphp/dnpa/obesity/childhood/prevalence.html (accessed January 10, 2009).
2. Mary Jo Stanley, RN MS, €œAssessing Prevalence of Emotional and Behavioral Problems in Suspended Middle School Students,€ The Journal of School Nursing 22 (2006): 40-47
3. €œRx for Behavior Problems in Pre-K,€ Preschool Matters, A publication of the National Institute for Early Education Research 5 (November/December 2007).
4. Walter S. Gilliam, PhD, €œPrekindergarteners Left Behind: Expulsion Rates in State Prekindergarten Programs,€ Foundation for Child Development Policy Brief, Series No. 3 (May 2005).
5. Cathy Huanqing Qi et al., €œBehavior Problems of Preschool Children From Low-Income Families: Review of the Literature,€ Topics in Early Childhood Special Education 162 (June 2005).
6. Kenneth Bock, M.D, Healing the New Childhood Epidemics: Autism, ADHD, Asthma, and Allergies (New York: Ballantine Books, 2007).
7. National Center for Health Statistics 2006, The CDC, http://www.cdc.gov/nchs/fastats/asthma.htm (accessed January 10, 2009).
8. American Academy of Asthma, Allergy and Immunology, www.aaai.org (accessed January 10, 2009).
9. National Center For Health Statistics, The CDC, http://www.cdc.gov/nchs/fastats/asthma.htm (accessed January 10, 2009).
10. The American College of Allergy, Asthma, & Immunology, €œAsthma Uncontrolled in 85% of Inner City Students,€ American College of Allergy, Asthma, & Immunology Online (July 10, 2006) http://www.acaai.org/public/linkpages/AsthmaInnerCity.htm (accessed August 15, 2009).
11. The Centers for Disease Control, NCHS Data Brief No. 10,by Amy M. Branum et al., The CDC, National Center for Health Statistics (October 2007).
12. Elizabeth Lipski, Digestive Wellness (New York: McGraw Hill, 2004) 90.
13.National Institute of Allergy and Infectious Diseases, €œFood Allergy: Report of the NIH Expert Panel on Food Allergy Research,€ NIH, http://www3.niaid.nih.gov/topics/foodAllergy/research/ReportFoodAllergy.htp (accessed August 3, 2009).
14. The Centers for Disease Control, NCHS Data Brief No. 10,by Amy M. Branum et al., The CDC, National Center for Health Statistics (October 2007).
15. Phil Lieberman, MD and John A. Anderson, MD, Allergic Diseases (Totowa, NJ: Human Press, 2007), 272.
16. The Centers for Disease Control, €œQuickStats: Percentage of Children Aged 5-17 Years Ever Having Diagnoses of Attention Deficit/Hyperactivity Disorder (ADHD) or Learning Disability (LD) by Sex and Diagnosis,€ Morbidity and Mortality Weekly 54, no. 43(November 2005): 1107, http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5443a8.htm (accessed September 9, 2009).
17. Lynn Waterhouse, €œAutism Overflows: Increasing Prevalence and Proliferating Theories,€ Neuropsychology Review 18 (2008) 273-286.
18. Sue Reid, €œOne child in 60 €˜suffers from a form of autism,€™€ The Daily Mail Online, http://www.dailymail.co.uk/news/article-1163606/One-child-60-suffers-form-autism.html (accessed August 3, 2009).
19. Autism Research Institute, €œRecently Released Data from the National Survey of Children€™s Health Reports that Autism Now Affects 1% of Children and is More Common Than Children€™s Cancer, Diabetes, and AIDS combined,€ Reuters, August 3, 2009 (accessed August 3, 2009).
20. Autism Research Institute, ARI Calls for Immediate Federal Response to New Autism Figures – Oct. ’09 (October 2009) http://www.autism.com (accessed October 6, 2009).
21. National Institutes of Mental Health, ADHD Booklet (2003) http://www.nimh.nih.gov/health/publications/attention-deficit-hyperactivity-disorder/adhd_booklet.pdf (accessed March 11, 2009); William E. Pelham PhD, et al., €œThe Economic Impact of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents,€ Ambulatory Pediatrics (January/February 2007): 1.
22. Melissa A Brotman et al., €œPrevalence, clinical correlates, and longitudinal course of severe mood dysregulation in children,€ Biological Psychiatry 60, no. 9 (2006): 991-997.
23. S. Sutton Hamilton et al., €œOppositional Defiant Disorder,€ American Family Physician, 78, no. 7 (October 2008): 861-866.
24. Natasha Campbell McBride, €œGAPS, the Gut and Psychology Syndrome€ (lecture, The Weston A. Price Foundation, Wise Traditions Conference, San Francisco, CA, November 8, 2008).
25. Carlos Blanco MD et al., €œMental Health of College Students and Their Non€“College-Attending Peers: Results From the National Epidemiologic Study on Alcohol and Related Conditions,€ Archives of General Psychiatry 65, no. 12 (2008): 1429-1437.
26. Tanya E. Froehlich, MD et al., €œPrevalence, Recognition, and Treatment of Attention-Deficit/Hyperactivity Disorder in a National Sample of US Children,€ Archives of Pediatric and Adolescent Medicine 161, no. 9 (2007): 857-864.
27. William E. Pelham PhD, et al., €œThe Economic Impact of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents,€ Ambulatory Pediatrics (January/February 2007).
28. Donna Jackson Nakazawa, The Autoimmune Epidemic (New York: Simon & Schuster, 2008).
29. C. Jakobsen, €œIncidence of ulcerative colitis and Crohn’s disease in Danish children: Still rising or leveling out?€ Journal of Crohn€™s & Colitis 2 (June 2008): 152-157; Johan van Limbergen et al., €œA detailed investigation into epidemiological risk factors for childhood onset inflammatory bowel disease in Scotland,€ Gastroenterology 134, no. 4 (2008): A189.
30. Children€™s Digestive Health and Nutrition Foundation, €œPediatric Celiac Disease€ www.celiachealth.org (accessed March 11, 2009).
31. MSNBC, €œCeliac disease cases quadruple in the United States,€ Reuters. July 10, 2009, http://www.msnbc.msn.com/id/31852701/ns/health-diet_and_nutrition/ (accessed July 11, 2009).
32. William E. Pelham PhD, et al., €œThe Economic Impact of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents,€ Ambulatory Pediatrics (January/February 2007).
33. Michael L. Ganz, €œThe lifetime distribution of incremental societal costs of autism,€ Archives of Pediatrics and Adolescent Medicine 161 (2007): 343-349.
34. Fighting Autism, €œU.S. Annual Economic Cost,€ www.fightingautism.org (accessed August 30, 2009).
35. The Autism Society of America, €œFacts and Statistics,€ http://www.autism-society.org/site/PageServer?pagename=asa_media_home (accessed August 30, 2009).
36. The National Autistic Society, €œEmployment,€ http://www.nas.org.uk/nas/jsp/polopoly.jsp?d=1937 (accessed August 28, 2009).
37. E. Michael Foster et al., €œThe High Costs of Aggression: Public Expenditures Resulting From Conduct Disorder,€ American Journal of Public Health 95, no. 10 (October 2005): 1767.
38. Centers for Disease Control and Prevention, €œAutism Information Center,€ http://www.cdc.gov/ncbddd/autism/faq_prevalence.htm (accessed March 5, 2009).
39. Chris PlauchÃ© Johnson, MD et al., €œIdentification and Evaluation of Children With Autism Spectrum Disorders,€ Pediatrics 120, no. 5 (November 2007).
40. PT Shattuck, €œThe Contribution of Diagnostic Substitution to the Growing Administrative Prevalence of Autism in US Special Education,€ Pediatrics 117, no. 4 (April 2006): 1028-1037.
41. Jacquelyn Bertrand, €œPrevalence of Autism in a United States Population: The Brick Township, New Jersey, Investigation€ Pediatrics 108, no. 5 (November 2001): 1155-116;
42. Irva Hertz-Picciotto and Lora Delwiche, €œThe Rise in Autism and the Role of Age at Diagnosis,€ Epidemiology 20, no. 1 (January 2009): 84-90.
43. Mark Blaxill, €œWhat€™s Going On? The Question of Time Trends in Autism,€ Public Health Reports 119, no. 5 (November 2004): 536 -352.
44. Thoughtful House Center for Children, €œAutism Diagnostic Substitution,€
45. FightingAutism, Austin, TX, http://www.fightingautism.org/idea/autism-diagnostic-substitution.php (accessed February 16, 2009).
46. The American Academy of Pediatrics, €œADHD,€ http://www.aap.org/publiced/br_adhd_faq.htm (accessed February 16, 2009).
47. Bruce P. Lanphear et al., €œIncreasing Prevalence of Recurrent Otitis Media Among Children in the United States,€ Pediatrics 99, no. 3 (March 1997): e1.
48. Dr. Robyn Cosford, €œOccult Infections, Streptococcus, Biofilms, PANDAS and MINDDD in Autism,€ (lecture, Defeat Autism Now Conference, San Diego, CA, October 2008).
49. The American Academy of Microbiology, €œProbiotic Microbes: The Scientific Basis,€ American Society for Microbiology, http://academy.asm.org/images/stories/documents/probioticmicrobesfull.pdf (accessed, March 14, 2009).
Overuse of Medication/Pharmaceuticals
1. Maggie Mahar, Money Driven Medicine (New York: Collins, 2006).
2. Jason A. Hawrelak et al., €œThe Causes of Intestinal Dysbiosis: A Review,€ Alternative Medicine Review 9, no. 2 (2004).
3. Union of Concerned Scientists, Hogging It!: Estimates of Antimicrobial Abuse in Livestock (Cambridge, MA: Union of Concerned Scientists 2001) http://www.ucsusa.org/assets/documents/food_and_agriculture/hog_chaps.pdf (accessed March 23, 2009).
4. Martin J. Blaser, €œWho are we: Indigenous microbes and the ecology of human diseases,€ European Molecular Biology Organization Report 7, no. 10 (2006).
5. Carl Erik Nord et al., €œEffect of Tigecycline on Normal Oropharyngeal and Intestinal Microflora,€ Antimicrobial Agents Chemotherapy 50, no. 10 (October 2006).
6. Carl Erik Nord and C Edlund, €œImpact of antimicrobial agents on human intestinal microflora,€ Journal of Chemotherapy 2 (1990): 218-237.
7. Williamson et al., €œConsultations for middle ear disease, antibiotic prescribing and risk factors for reattendance: a case-linked cohort study,€ British Journal of General Practice 56, no. 524 (March 2006): 170-175.
8. MJ Benotti et al., €œPharmaceuticals and endocrine disrupting compounds in U.S. drinking water,€ Environmental Science Technology 43, no. 3 (February 2009): 597-603.
9. David L. Smith et al., €œAgricultural Antibiotics and Human Health,€ PLoS Medicine 2, no. 8 (August 2005).
10. Jeremy K. Nicholson et al., €œGut Microorganisms, mammalian metabolism and personalized health care,€ Nature Reviews Microbiology 3 (April 2005).
11. Jack Challem, The Inflammation Syndrome (Hoboken, NJ: Wiley and Son, 2003).
12. D. Adebayo and I. Bjarnason, €œIs non-steroidal anti-inflammatory drug (NSAID) enteropathy clinically more important than NSAID gastropathy?€ Postgraduate Medical Journal 82, no. 965 (March 2006): 186-191.
13. Simon Smale & Ingvar Bjarnason, €œDetermining small bowel integrity following drug treatment,€ British Journal of Clinical Pharmacology 56 (2003): 284-291.
14. Mohammed A. S. Alem and L. Julia Douglas, €œEffects of Aspirin and Other Nonsteroidal Anti-Inflammatory Drugs on Biofilms and Planktonic Cells of Candida albicans,€ Antimicrobial Agents and Chemotherapy 48, no. 1 (January 2004).
15. JM Hassing et al., €œAcetaminophen-induced glutathione depletion in diabetic rats,€ Research Communications Chemical Pathology and Pharmacology 25, no. 1 (July 1979): 3-11.
16. €œAutistic children€™s abnormal metabolic profile findings,€ Medical News Today April 3, 2005, http://www.medicalnewstoday.com/articles/22178.php (accessed August 25, 2009)
17. James, S. Jill et al. 2004. Metabolic biomakers of increased oxidative stress and impaired methylation capacity in children with autism. American Journal of Clinical Nutrition 80, no. 6 (December): 1611-1617.
18. Sidney MacDonald Baker, €œCanaries and Miners,€ Alternative Therapies in Health and Medicine 14 no. 6 (November/December 2008): 24-26.
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